GrippeEspagneV1, Main, Exploration, bibRecord, 000394

Oseltamivir-resistant pandemic influenza a (H1N1) 2009 viruses in Spain.

Identifieur interne : 000394 ( Main/Exploration ); précédent : 000393; suivant : 000395

Oseltamivir-resistant pandemic influenza a (H1N1) 2009 viruses in Spain.

Auteurs : Juan Ledesma [Espagne] ; Diego Vicente ; Francisco Pozo ; Gustavo Cilla ; Sonia Pérez Castro ; Jonathan Suárez Fernández ; Mercedes Pérez Ruiz ; José María Navarro ; Juan Carlos Galán ; Mirian Fernández ; Jordi Reina ; Amparo Larrauri ; María Teresa Cuevas ; Inmaculada Casas ; Pilar Pérez Bre A

Source :

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [ 1873-5967 ] ; 2011.

RBID : pubmed:21592854

Descripteurs français

KwdFr :
- Adulte (MeSH), Analyse de séquence d'ADN (MeSH), Antiviraux (pharmacologie), Enfant (MeSH), Enfant d'âge préscolaire (MeSH), Espagne (épidémiologie), Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains (MeSH), Hybridation d'acides nucléiques (MeSH), Mutation faux-sens (MeSH), Mâle (MeSH), Nourrisson (MeSH), Oséltamivir (pharmacologie), Pandémies (MeSH), Protéines virales (génétique), Prévalence (MeSH), RT-PCR (MeSH), Résistance virale aux médicaments (MeSH), Sialidase (génétique), Sous-type H1N1 du virus de la grippe A (effets des médicaments et des substances chimiques), Sous-type H1N1 du virus de la grippe A (isolement et purification), Substitution d'acide aminé (génétique), Sujet âgé (MeSH).
MESH :
- effets des médicaments et des substances chimiques : Sous-type H1N1 du virus de la grippe A.
- génétique : Protéines virales, Sialidase, Substitution d'acide aminé.
- isolement et purification : Sous-type H1N1 du virus de la grippe A.
- pharmacologie : Antiviraux, Oséltamivir.
- virologie : Grippe humaine.
- épidémiologie : Espagne, Grippe humaine.
- Adulte, Analyse de séquence d'ADN, Enfant, Enfant d'âge préscolaire, Humains, Hybridation d'acides nucléiques, Mutation faux-sens, Mâle, Nourrisson, Pandémies, Prévalence, RT-PCR, Résistance virale aux médicaments, Sujet âgé.
Wicri :
- geographic : Espagne.

English descriptors

KwdEn :
- Adult (MeSH), Aged (MeSH), Amino Acid Substitution (genetics), Antiviral Agents (pharmacology), Child (MeSH), Child, Preschool (MeSH), Drug Resistance, Viral (MeSH), Humans (MeSH), Infant (MeSH), Influenza A Virus, H1N1 Subtype (drug effects), Influenza A Virus, H1N1 Subtype (isolation & purification), Influenza, Human (epidemiology), Influenza, Human (virology), Male (MeSH), Mutation, Missense (MeSH), Neuraminidase (genetics), Nucleic Acid Hybridization (MeSH), Oseltamivir (pharmacology), Pandemics (MeSH), Prevalence (MeSH), Reverse Transcriptase Polymerase Chain Reaction (MeSH), Sequence Analysis, DNA (MeSH), Spain (epidemiology), Viral Proteins (genetics).
MESH :
- chemical , genetics : Neuraminidase, Viral Proteins.
- chemical , pharmacology : Antiviral Agents, Oseltamivir.
- geographic , epidemiology : Spain.
- drug effects : Influenza A Virus, H1N1 Subtype.
- epidemiology : Influenza, Human.
- genetics : Amino Acid Substitution.
- isolation & purification : Influenza A Virus, H1N1 Subtype.
- virology : Influenza, Human.
- Adult, Aged, Child, Child, Preschool, Drug Resistance, Viral, Humans, Infant, Male, Mutation, Missense, Nucleic Acid Hybridization, Pandemics, Prevalence, Reverse Transcriptase Polymerase Chain Reaction, Sequence Analysis, DNA.

Abstract

BACKGROUND

Pandemic influenza A (H1N1) 2009 virus appeared in Spain on April 25, 2009 for the first time. This new virus was adamantane-resistant but it was sensitive to neuraminidase (NA) inhibitors oseltamivir and zanamivir.

OBJECTIVES

To detect oseltamivir-resistant pandemic influenza A (H1N1) 2009 viruses by the Spanish Influenza Surveillance System (SISS) and a possible spread of oseltamivir-resistant viruses in Spain since starting of the pandemic situation.

STUDY DESIGN

A total of 1229 respiratory samples taken from 413 severe and 766 non-severe patients with confirmed viral detection of pandemic influenza A (H1N1) 2009 viruses from different Spanish regions were analyzed for the specific detection of the H275Y mutation in NA between April 2009 and May 2010.

RESULTS

H275Y NA substitution was found in 8 patients infected with pandemic influenza A (H1N1) 2009 viruses collected in November and December 2009 and in January 2010. All oseltamivir-resistant viruses were detected in severe patients (8/413, 1.93%) who previously received treatment with oseltamivir. Six of these patients were immunocompromised.

CONCLUSION

In Spain, the number of oseltamivir-resistant pandemic influenza A (H1N1) 2009 viruses is until now very low. No evidence for any spread of oseltamivir-resistant H1N1 viruses is achieved in our Country.

DOI: 10.1016/j.jcv.2011.04.008
PubMed: 21592854

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 00374
to stream Main, to step Curation: 000374

Le document en format XML

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<term>Aged (MeSH)</term>
<term>Amino Acid Substitution (genetics)</term>
<term>Antiviral Agents (pharmacology)</term>
<term>Child (MeSH)</term>
<term>Child, Preschool (MeSH)</term>
<term>Drug Resistance, Viral (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Infant (MeSH)</term>
<term>Influenza A Virus, H1N1 Subtype (drug effects)</term>
<term>Influenza A Virus, H1N1 Subtype (isolation & purification)</term>
<term>Influenza, Human (epidemiology)</term>
<term>Influenza, Human (virology)</term>
<term>Male (MeSH)</term>
<term>Mutation, Missense (MeSH)</term>
<term>Neuraminidase (genetics)</term>
<term>Nucleic Acid Hybridization (MeSH)</term>
<term>Oseltamivir (pharmacology)</term>
<term>Pandemics (MeSH)</term>
<term>Prevalence (MeSH)</term>
<term>Reverse Transcriptase Polymerase Chain Reaction (MeSH)</term>
<term>Sequence Analysis, DNA (MeSH)</term>
<term>Spain (epidemiology)</term>
<term>Viral Proteins (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term>
<term>Analyse de séquence d'ADN (MeSH)</term>
<term>Antiviraux (pharmacologie)</term>
<term>Enfant (MeSH)</term>
<term>Enfant d'âge préscolaire (MeSH)</term>
<term>Espagne (épidémiologie)</term>
<term>Grippe humaine (virologie)</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Humains (MeSH)</term>
<term>Hybridation d'acides nucléiques (MeSH)</term>
<term>Mutation faux-sens (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Nourrisson (MeSH)</term>
<term>Oséltamivir (pharmacologie)</term>
<term>Pandémies (MeSH)</term>
<term>Protéines virales (génétique)</term>
<term>Prévalence (MeSH)</term>
<term>RT-PCR (MeSH)</term>
<term>Résistance virale aux médicaments (MeSH)</term>
<term>Sialidase (génétique)</term>
<term>Sous-type H1N1 du virus de la grippe A (effets des médicaments et des substances chimiques)</term>
<term>Sous-type H1N1 du virus de la grippe A (isolement et purification)</term>
<term>Substitution d'acide aminé (génétique)</term>
<term>Sujet âgé (MeSH)</term>
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<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Neuraminidase</term>
<term>Viral Proteins</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term>
<term>Oseltamivir</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Spain</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Amino Acid Substitution</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines virales</term>
<term>Sialidase</term>
<term>Substitution d'acide aminé</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term>
<term>Oséltamivir</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Espagne</term>
<term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Drug Resistance, Viral</term>
<term>Humans</term>
<term>Infant</term>
<term>Male</term>
<term>Mutation, Missense</term>
<term>Nucleic Acid Hybridization</term>
<term>Pandemics</term>
<term>Prevalence</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
<term>Sequence Analysis, DNA</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Analyse de séquence d'ADN</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Humains</term>
<term>Hybridation d'acides nucléiques</term>
<term>Mutation faux-sens</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Pandémies</term>
<term>Prévalence</term>
<term>RT-PCR</term>
<term>Résistance virale aux médicaments</term>
<term>Sujet âgé</term>
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<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>Pandemic influenza A (H1N1) 2009 virus appeared in Spain on April 25, 2009 for the first time. This new virus was adamantane-resistant but it was sensitive to neuraminidase (NA) inhibitors oseltamivir and zanamivir.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b>
</p>
<p>To detect oseltamivir-resistant pandemic influenza A (H1N1) 2009 viruses by the Spanish Influenza Surveillance System (SISS) and a possible spread of oseltamivir-resistant viruses in Spain since starting of the pandemic situation.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>STUDY DESIGN</b>
</p>
<p>A total of 1229 respiratory samples taken from 413 severe and 766 non-severe patients with confirmed viral detection of pandemic influenza A (H1N1) 2009 viruses from different Spanish regions were analyzed for the specific detection of the H275Y mutation in NA between April 2009 and May 2010.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>H275Y NA substitution was found in 8 patients infected with pandemic influenza A (H1N1) 2009 viruses collected in November and December 2009 and in January 2010. All oseltamivir-resistant viruses were detected in severe patients (8/413, 1.93%) who previously received treatment with oseltamivir. Six of these patients were immunocompromised.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>In Spain, the number of oseltamivir-resistant pandemic influenza A (H1N1) 2009 viruses is until now very low. No evidence for any spread of oseltamivir-resistant H1N1 viruses is achieved in our Country.</p>
</div>
</front>
</TEI>
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<DateCompleted><Year>2011</Year>
<Month>09</Month>
<Day>26</Day>
</DateCompleted>
<DateRevised><Year>2013</Year>
<Month>11</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-5967</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>51</Volume>
<Issue>3</Issue>
<PubDate><Year>2011</Year>
<Month>Jul</Month>
</PubDate>
</JournalIssue>
<Title>Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology</Title>
<ISOAbbreviation>J. Clin. Virol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Oseltamivir-resistant pandemic influenza a (H1N1) 2009 viruses in Spain.</ArticleTitle>
<Pagination><MedlinePgn>205-8</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jcv.2011.04.008</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Pandemic influenza A (H1N1) 2009 virus appeared in Spain on April 25, 2009 for the first time. This new virus was adamantane-resistant but it was sensitive to neuraminidase (NA) inhibitors oseltamivir and zanamivir.</AbstractText>
<AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To detect oseltamivir-resistant pandemic influenza A (H1N1) 2009 viruses by the Spanish Influenza Surveillance System (SISS) and a possible spread of oseltamivir-resistant viruses in Spain since starting of the pandemic situation.</AbstractText>
<AbstractText Label="STUDY DESIGN" NlmCategory="METHODS">A total of 1229 respiratory samples taken from 413 severe and 766 non-severe patients with confirmed viral detection of pandemic influenza A (H1N1) 2009 viruses from different Spanish regions were analyzed for the specific detection of the H275Y mutation in NA between April 2009 and May 2010.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">H275Y NA substitution was found in 8 patients infected with pandemic influenza A (H1N1) 2009 viruses collected in November and December 2009 and in January 2010. All oseltamivir-resistant viruses were detected in severe patients (8/413, 1.93%) who previously received treatment with oseltamivir. Six of these patients were immunocompromised.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">In Spain, the number of oseltamivir-resistant pandemic influenza A (H1N1) 2009 viruses is until now very low. No evidence for any spread of oseltamivir-resistant H1N1 viruses is achieved in our Country.</AbstractText>
<CopyrightInformation>Copyright © 2011 Elsevier B.V. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ledesma</LastName>
<ForeName>Juan</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Centro Nacional de Gripe, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain. jledesmam@isciii.es</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vicente</LastName>
<ForeName>Diego</ForeName>
<Initials>D</Initials>
</Author>
<Author ValidYN="Y"><LastName>Pozo</LastName>
<ForeName>Francisco</ForeName>
<Initials>F</Initials>
</Author>
<Author ValidYN="Y"><LastName>Cilla</LastName>
<ForeName>Gustavo</ForeName>
<Initials>G</Initials>
</Author>
<Author ValidYN="Y"><LastName>Castro</LastName>
<ForeName>Sonia Pérez</ForeName>
<Initials>SP</Initials>
</Author>
<Author ValidYN="Y"><LastName>Fernández</LastName>
<ForeName>Jonathan Suárez</ForeName>
<Initials>JS</Initials>
</Author>
<Author ValidYN="Y"><LastName>Ruiz</LastName>
<ForeName>Mercedes Pérez</ForeName>
<Initials>MP</Initials>
</Author>
<Author ValidYN="Y"><LastName>Navarro</LastName>
<ForeName>José María</ForeName>
<Initials>JM</Initials>
</Author>
<Author ValidYN="Y"><LastName>Galán</LastName>
<ForeName>Juan Carlos</ForeName>
<Initials>JC</Initials>
</Author>
<Author ValidYN="Y"><LastName>Fernández</LastName>
<ForeName>Mirian</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Reina</LastName>
<ForeName>Jordi</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Larrauri</LastName>
<ForeName>Amparo</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Cuevas</LastName>
<ForeName>María Teresa</ForeName>
<Initials>MT</Initials>
</Author>
<Author ValidYN="Y"><LastName>Casas</LastName>
<ForeName>Inmaculada</ForeName>
<Initials>I</Initials>
</Author>
<Author ValidYN="Y"><LastName>Breña</LastName>
<ForeName>Pilar Pérez</ForeName>
<Initials>PP</Initials>
</Author>
<Author ValidYN="Y"><CollectiveName>Spanish Influenza Surveillance System (SISS)</CollectiveName>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2011</Year>
<Month>05</Month>
<Day>17</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Netherlands</Country>
<MedlineTA>J Clin Virol</MedlineTA>
<NlmUniqueID>9815671</NlmUniqueID>
<ISSNLinking>1386-6532</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014764">Viral Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>20O93L6F9H</RegistryNumber>
<NameOfSubstance UI="D053139">Oseltamivir</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.2.1.18</RegistryNumber>
<NameOfSubstance UI="C487630">NA protein, influenza A virus</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.2.1.18</RegistryNumber>
<NameOfSubstance UI="D009439">Neuraminidase</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019943" MajorTopicYN="N">Amino Acid Substitution</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D024882" MajorTopicYN="Y">Drug Resistance, Viral</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020125" MajorTopicYN="N">Mutation, Missense</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009439" MajorTopicYN="N">Neuraminidase</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009693" MajorTopicYN="N">Nucleic Acid Hybridization</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053139" MajorTopicYN="N">Oseltamivir</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="Y">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020133" MajorTopicYN="N">Reverse Transcriptase Polymerase Chain Reaction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017422" MajorTopicYN="N">Sequence Analysis, DNA</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014764" MajorTopicYN="N">Viral Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
</MeshHeadingList>
<InvestigatorList><Investigator ValidYN="Y"><LastName>Breña</LastName>
<ForeName>Pilar Pérez</ForeName>
<Initials>PP</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Casas</LastName>
<ForeName>Immaculada</ForeName>
<Initials>I</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Pozo</LastName>
<ForeName>Francisco</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ledesma</LastName>
<ForeName>Juan</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Cuevas</LastName>
<ForeName>María Teresa</ForeName>
<Initials>MT</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>de Lejarazu</LastName>
<ForeName>Raúl Ortiz</ForeName>
<Initials>RO</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Eiros</LastName>
<ForeName>José María</ForeName>
<Initials>JM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Pumarola</LastName>
<ForeName>Tomás</ForeName>
<Initials>T</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Marcos</LastName>
<ForeName>María Ángeles</ForeName>
<Initials>MÁ</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Navarro</LastName>
<ForeName>José María</ForeName>
<Initials>JM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ruiz</LastName>
<ForeName>Mercedes Pérez</ForeName>
<Initials>MP</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Omeñaca</LastName>
<ForeName>Manuel</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>de Oña</LastName>
<ForeName>María</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Melón</LastName>
<ForeName>Santiago</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Reina</LastName>
<ForeName>Jordi</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Pérez</LastName>
<ForeName>Carmen</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Sanjuán</LastName>
<ForeName>María Victoria</ForeName>
<Initials>MV</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Gimeno</LastName>
<ForeName>Concepción</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Sánchez</LastName>
<ForeName>Pilar Teno</ForeName>
<Initials>PT</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Rodriguez</LastName>
<ForeName>Guadalupe</ForeName>
<Initials>G</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Galán</LastName>
<ForeName>Juan Carlos</ForeName>
<Initials>JC</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Fernández</LastName>
<ForeName>Mirian</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Pérez-Trallero</LastName>
<ForeName>Emilio</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Cilla</LastName>
<ForeName>Gustavo</ForeName>
<Initials>G</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Vicente</LastName>
<ForeName>Diego</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Blasco</LastName>
<ForeName>Mirian</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Barba</LastName>
<ForeName>José López</ForeName>
<Initials>JL</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Miragaya</LastName>
<ForeName>Isabel López</ForeName>
<Initials>IL</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Costa</LastName>
<ForeName>Juan Garciá</ForeName>
<Initials>JG</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Docón</LastName>
<ForeName>Antonio Moreno</ForeName>
<Initials>AM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Madrid</LastName>
<ForeName>Juan Carlos Navarro</ForeName>
<Initials>JC</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Mayoral</LastName>
<ForeName>Jose María</ForeName>
<Initials>JM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>de Ágreda</LastName>
<ForeName>Juan Pablo Alonzo Pérez</ForeName>
<Initials>JP</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Martins</LastName>
<ForeName>Mario Margolles</ForeName>
<Initials>MM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Riutort</LastName>
<ForeName>Antonio Nicolau</ForeName>
<Initials>AN</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>González</LastName>
<ForeName>Lucas</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Viloria</LastName>
<ForeName>Luis J</ForeName>
<Initials>LJ</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Gutierrez</LastName>
<ForeName>Gonzalo</ForeName>
<Initials>G</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Vega</LastName>
<ForeName>Tomás</ForeName>
<Initials>T</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Martínez</LastName>
<ForeName>Ana</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Zurriaga</LastName>
<ForeName>Oscar</ForeName>
<Initials>O</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ramos</LastName>
<ForeName>Julián Mauros</ForeName>
<Initials>JM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ordobás</LastName>
<ForeName>María</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Purriños</LastName>
<ForeName>María Jesús</ForeName>
<Initials>MJ</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Castilla</LastName>
<ForeName>Jesús</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Arteagoitia</LastName>
<ForeName>José María</ForeName>
<Initials>JM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Perucha</LastName>
<ForeName>Milagros</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Rivas</LastName>
<ForeName>Ana</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Castrillejo</LastName>
<ForeName>Daniel</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>García</LastName>
<ForeName>Rocío</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Larrauri</LastName>
<ForeName>Amparo</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Jorge</LastName>
<ForeName>Silvia Jimenez</ForeName>
<Initials>SJ</Initials>
</Investigator>
</InvestigatorList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2010</Year>
<Month>11</Month>
<Day>30</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2011</Year>
<Month>04</Month>
<Day>11</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2011</Year>
<Month>04</Month>
<Day>20</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2011</Year>
<Month>5</Month>
<Day>20</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2011</Year>
<Month>5</Month>
<Day>20</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2011</Year>
<Month>9</Month>
<Day>29</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">21592854</ArticleId>
<ArticleId IdType="pii">S1386-6532(11)00148-X</ArticleId>
<ArticleId IdType="doi">10.1016/j.jcv.2011.04.008</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Espagne</li>
</country>
<region><li>Communauté de Madrid</li>
</region>
<settlement><li>Madrid</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Bre A, Pilar Perez" sort="Bre A, Pilar Perez" uniqKey="Bre A P" first="Pilar Pérez" last="Bre A">Pilar Pérez Bre A</name>
<name sortKey="Casas, Inmaculada" sort="Casas, Inmaculada" uniqKey="Casas I" first="Inmaculada" last="Casas">Inmaculada Casas</name>
<name sortKey="Castro, Sonia Perez" sort="Castro, Sonia Perez" uniqKey="Castro S" first="Sonia Pérez" last="Castro">Sonia Pérez Castro</name>
<name sortKey="Cilla, Gustavo" sort="Cilla, Gustavo" uniqKey="Cilla G" first="Gustavo" last="Cilla">Gustavo Cilla</name>
<name sortKey="Cuevas, Maria Teresa" sort="Cuevas, Maria Teresa" uniqKey="Cuevas M" first="María Teresa" last="Cuevas">María Teresa Cuevas</name>
<name sortKey="Fernandez, Jonathan Suarez" sort="Fernandez, Jonathan Suarez" uniqKey="Fernandez J" first="Jonathan Suárez" last="Fernández">Jonathan Suárez Fernández</name>
<name sortKey="Fernandez, Mirian" sort="Fernandez, Mirian" uniqKey="Fernandez M" first="Mirian" last="Fernández">Mirian Fernández</name>
<name sortKey="Galan, Juan Carlos" sort="Galan, Juan Carlos" uniqKey="Galan J" first="Juan Carlos" last="Galán">Juan Carlos Galán</name>
<name sortKey="Larrauri, Amparo" sort="Larrauri, Amparo" uniqKey="Larrauri A" first="Amparo" last="Larrauri">Amparo Larrauri</name>
<name sortKey="Navarro, Jose Maria" sort="Navarro, Jose Maria" uniqKey="Navarro J" first="José María" last="Navarro">José María Navarro</name>
<name sortKey="Pozo, Francisco" sort="Pozo, Francisco" uniqKey="Pozo F" first="Francisco" last="Pozo">Francisco Pozo</name>
<name sortKey="Reina, Jordi" sort="Reina, Jordi" uniqKey="Reina J" first="Jordi" last="Reina">Jordi Reina</name>
<name sortKey="Ruiz, Mercedes Perez" sort="Ruiz, Mercedes Perez" uniqKey="Ruiz M" first="Mercedes Pérez" last="Ruiz">Mercedes Pérez Ruiz</name>
<name sortKey="Vicente, Diego" sort="Vicente, Diego" uniqKey="Vicente D" first="Diego" last="Vicente">Diego Vicente</name>
</noCountry>
<country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Ledesma, Juan" sort="Ledesma, Juan" uniqKey="Ledesma J" first="Juan" last="Ledesma">Juan Ledesma</name>
</region>
</country>
</tree>
</affiliations>
</record>

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	Serveur d'exploration sur la grippe en Espagne
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Serveur d'exploration sur la grippe en Espagne

Oseltamivir-resistant pandemic influenza a (H1N1) 2009 viruses in Spain.

Oseltamivir-resistant pandemic influenza a (H1N1) 2009 viruses in Spain.

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